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Issue 20, 2008
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Phorbasins G–K: new cytotoxic diterpenes from a southern Australian marine sponge, Phorbas sp.

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Abstract

Fractionation of a cytotoxic extract obtained from a southern Australian marine sponge, Phorbas sp., yielded the known diterpenes phorbasins B–F (1–5) together with five new members of the phorbasin family, phorbasins G–K (6–10). Structures were assigned to the new phorbasins based on detailed spectroscopic analysis. A preliminary structure activity relationship (SAR) evaluation based on the co-metabolites phorbasins B–K (1–10) revealed aspects of the phorbasin pharmacophore.

Graphical abstract: Phorbasins G–K: new cytotoxic diterpenes from a southern Australian marine sponge, Phorbas sp.

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Supplementary files

Article information


Submitted
27 May 2008
Accepted
21 Jul 2008
First published
28 Aug 2008

Org. Biomol. Chem., 2008,6, 3811-3815
Article type
Paper

Phorbasins G–K: new cytotoxic diterpenes from a southern Australian marine sponge, Phorbas sp.

H. Zhang, J. M. Major, R. J. Lewis and R. J. Capon, Org. Biomol. Chem., 2008, 6, 3811
DOI: 10.1039/B808866G

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