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Issue 21, 2008
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Controlling the activity of peptides and proteins with smart nucleic acid–protein hybrids

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Abstract

Oligonucleotidepeptide conjugates have frequently been used to control the localisation of the conjugate molecule. For example, the oligonucleotide segment has allowed spatially addressed immobilization of peptides and proteins on DNA-arrays via hybridisation while the peptide part has most frequently been used to confer transfer of oligonucleotide cargo into live cells. The regulation of functional properties such as the affinity of these bioconjugates for protein targets has rarely been addressed. This review article describes the current developments in the application of smart oligonucleotidepeptide hybrids. The mutual recognition between nucleic acid segments is used to constrain the structure or control the distance between peptide and protein segments. Application of these new type of oligonucleotidepeptide hybrids allowed not only the regulation of binding affinity of peptide ligands but also control of enzymatic and optical activity of proteins.

Graphical abstract: Controlling the activity of peptides and proteins with smart nucleic acid–protein hybrids

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Article information


Submitted
08 May 2008
Accepted
25 Jul 2008
First published
28 Aug 2008

Org. Biomol. Chem., 2008,6, 3881-3887
Article type
Emerging Area

Controlling the activity of peptides and proteins with smart nucleic acid–protein hybrids

L. Röglin and O. Seitz, Org. Biomol. Chem., 2008, 6, 3881
DOI: 10.1039/B807838F

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