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Issue 15, 2008
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Trachycladindoles A–G: cytotoxic heterocycles from an Australian marine sponge, Trachycladus laevispirulifer

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Abstract

A southern Australian marine sponge, Trachycladus laevispirulifer, yielded the cytotoxic agents trachycladindoles A–G (1–7) as a selection of novel indole-2-carboxylic acids bearing a 2-amino-4,5-dihydroimidazole moiety. The trachycladindoles displayed promising selective cytotoxicity against a panel of human cancer cell lines and their structures were assigned on the basis of detailed spectroscopic analysis. Preliminary structure activity relationship (SAR) investigations by co-metabolite defined structural features key to the trachycladindole pharmacophore, highlighting an unusual bioactive molecular motif deserving of future investigation.

Graphical abstract: Trachycladindoles A–G: cytotoxic heterocycles from an Australian marine sponge, Trachycladus laevispirulifer

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Supplementary files

Article information


Submitted
28 Feb 2008
Accepted
08 May 2008
First published
29 May 2008

Org. Biomol. Chem., 2008,6, 2765-2771
Article type
Paper

Trachycladindoles A–G: cytotoxic heterocycles from an Australian marine sponge, Trachycladus laevispirulifer

R. J. Capon, C. Peng and C. Dooms, Org. Biomol. Chem., 2008, 6, 2765
DOI: 10.1039/B803455A

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