Issue 15, 2008
From the journal:

Organic & Biomolecular Chemistry

Development of a practical Buchwald–Hartwig aminearylation protocol using a conveniently prepared (NHC)Pd(R-allyl)Cl catalyst†

Mark J. Cawley,a   F. Geoffrey N. Cloke,b   Richard J. Fitzmaurice,a   Stuart E. Pearson,c   James S. Scottc  and  Stephen Caddick*a  

* Corresponding authors

a Department of Chemistry, University College London, London, UK
E-mail: s.caddick@ucl.ac.uk

b Department of Chemistry and Biochemistry, University of Sussex, Brighton, UK

c AstraZeneca, Alderley Park, Mereside, Cheshire, UK

Abstract

Continuing efforts to establish a more general “user-friendly” protocol for the palladium-catalysed arylation of amines (Buchwald–Hartwig reaction) are described herein. Significant advances have been made through the use of the versatile (SIPr)Pd(methallyl)Cl complex in conjunction with the reliable base lithium hexamethyldisilazide (LHMDS).

Graphical abstract: Development of a practical Buchwald–Hartwig amine arylation protocol using a conveniently prepared (NHC)Pd(R-allyl)Cl catalyst

About
Cited by
Related
Download options Please wait...

Supplementary files

Article information

DOI
https://doi.org/10.1039/B801479E
Article type
Paper
Submitted
28 Jan 2008
Accepted
22 Apr 2008
First published
06 Jun 2008

Org. Biomol. Chem., 2008,6, 2820-2825

Permissions

Request permissions

Development of a practical Buchwald–Hartwig amine arylation protocol using a conveniently prepared (NHC)Pd(R-allyl)Cl catalyst

M. J. Cawley, F. G. N. Cloke, R. J. Fitzmaurice, S. E. Pearson, J. S. Scott and S. Caddick, Org. Biomol. Chem., 2008, 6, 2820 DOI: 10.1039/B801479E

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements