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Issue 8, 2008
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Recent advances in enantioselective [2 + 2 + 2] cycloaddition

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Abstract

Enantioselective cycloaddition using chiral transition metal catalysts is an atom-economical and efficient synthetic tool for the construction of chiral carbo- and heterocyclic skeletons. This short account discloses our recent results of inter- and intramolecular enantioselective [2 + 2 + 2] cycloadditions of alkyne and/or alkene moiety(ies). Chiral iridium complexes catalyzed the alkyne trimerization for the generation of axial chirality(ies), and chiral rhodium ones catalyzed alkynealkynealkene cyclization for the generation of a quaternary carbon including spirocyclic system.

Graphical abstract: Recent advances in enantioselective [2 + 2 + 2] cycloaddition

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Publication details

The article was received on 03 Jan 2008, accepted on 15 Feb 2008 and first published on 12 Mar 2008


Article type: Emerging Area
DOI: 10.1039/B720031E
Citation: Org. Biomol. Chem., 2008,6, 1317-1323
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    Recent advances in enantioselective [2 + 2 + 2] cycloaddition

    T. Shibata and K. Tsuchikama, Org. Biomol. Chem., 2008, 6, 1317
    DOI: 10.1039/B720031E

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