Issue 22, 2008
From the journal:

Organic & Biomolecular Chemistry

A modular approach to catalyst hydrophobicity for an asymmetric aldol reaction in a biphasic aqueous environment†

Marco Lombardo,*a   Srinivasan Easwar,a   Alessandro De Marco,a   Filippo Pasia  and  Claudio Trombini*a  

* Corresponding authors

a Dipartimento di Chimica “G. Ciamician”, Università di Bologna, via Selmi 2, Bologna, Italy
E-mail: marco.lombardo@unibo.it, claudio.trombini@unibo.it
Fax: +39 051 2099558
Tel: +39 051 2099513

Abstract

Catalyst 5, an ion pair consisting of a hydrophilic cation and a lipophilic anion, fulfils the solubility requirements needed to couple efficiency (enantioselectivities and anti-diastereoselectivities up to ≥99%) and catalyst recyclability in asymmetric aldol reactions under aqueous biphasic conditions.

Graphical abstract: A modular approach to catalyst hydrophobicity for an asymmetric aldol reaction in a biphasic aqueous environment

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Article information

DOI
https://doi.org/10.1039/B812607K
Article type
Paper
Submitted
22 Jul 2008
Accepted
19 Aug 2008
First published
29 Sep 2008

Org. Biomol. Chem., 2008,6, 4224-4229

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A modular approach to catalyst hydrophobicity for an asymmetric aldol reaction in a biphasic aqueous environment

M. Lombardo, S. Easwar, A. De Marco, F. Pasi and C. Trombini, Org. Biomol. Chem., 2008, 6, 4224 DOI: 10.1039/B812607K

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