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Issue 19, 2008
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Copper-free ‘click’: 1,3-dipolar cycloaddition of azides and arynes

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Abstract

Arynes formed through fluoride-promoted ortho-elimination of o-(trimethylsilyl)aryl triflates can undergo [3 + 2] cycloaddition with various azides to form substituted benzotriazoles. The rapid reaction times and mild conditions make this an attractive variation of the classical ‘click’ reaction of azides and alkynes.

Graphical abstract: Copper-free ‘click’: 1,3-dipolar cycloaddition of azides and arynes

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Publication details

The article was received on 21 Jul 2008, accepted on 04 Aug 2008 and first published on 13 Aug 2008


Article type: Communication
DOI: 10.1039/B812403E
Citation: Org. Biomol. Chem., 2008,6, 3461-3463

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    Copper-free ‘click’: 1,3-dipolar cycloaddition of azides and arynes

    L. Campbell-Verduyn, P. H. Elsinga, L. Mirfeizi, R. A. Dierckx and B. L. Feringa, Org. Biomol. Chem., 2008, 6, 3461
    DOI: 10.1039/B812403E

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