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Issue 19, 2008
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Synthesis and conformational analysis of cyclic analogues of inverse γ-turns

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Abstract

γ-Turn analogues comprising a modified dipeptide constrained in an eleven-membered ring were prepared by alkene metathesis and analysed by NMR and molecular modelling studies. The results reveal that some of the cyclic analogues form inverse γ-turns and preferentially adopt conformations determined by the identity of the incorporated amino acid residues and the nature of the constraining linker (E/Z-alkene or alkane).

Graphical abstract: Synthesis and conformational analysis of cyclic analogues of inverse γ-turns

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Supplementary files

Article information


Submitted
28 May 2008
Accepted
04 Jul 2008
First published
07 Aug 2008

Org. Biomol. Chem., 2008,6, 3476-3485
Article type
Paper

Synthesis and conformational analysis of cyclic analogues of inverse γ-turns

M. Kaewpet, B. Odell, M. A. King, B. Banerji, C. J. Schofield and T. D. W. Claridge, Org. Biomol. Chem., 2008, 6, 3476 DOI: 10.1039/B808954J

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