Issue 17, 2008
From the journal:

Organic & Biomolecular Chemistry

Generation of molecular diversity using a complexity-generating MCR-platform towards triazinane diones†

Bas Groenendaal,a   Eelco Ruijter,a   Frans J. J. de Kanter,a   Martin Lutz,b   Anthony L. Spekb  and  Romano V. A. Orru*a  

* Corresponding authors

a Department of Chemistry and Pharmaceutical Sciences, Vrije Universiteit Amsterdam, De Boelelaan 1083, Amsterdam, HV, The Netherlands
E-mail: orru@few.vu.nl
Fax: +31 20 5987488
Tel: +31 20 5987447

b Bijvoet Center for Biomolecular Research, Crystal and Structural Chemistry, Utrecht University, Padualaan 8, Utrecht, CH, The Netherlands

Abstract

Triazinane diones, readily generated by a recently reported multicomponent reaction, can be easily alkylated with various alkyl halides, allowing a wide variety of complexity-generating secondary reactions. Because of the high variability of the initial multicomponent reactions and the multiple possibilities for participation of substituents in the secondary reactions, a highly diverse set of complex products was obtained in short and efficient reaction sequences.

Graphical abstract: Generation of molecular diversity using a complexity-generating MCR-platform towards triazinane diones

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Article information

DOI
https://doi.org/10.1039/B807138A
Article type
Paper
Submitted
28 Apr 2008
Accepted
05 Jun 2008
First published
03 Jul 2008

Org. Biomol. Chem., 2008,6, 3158-3165

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Generation of molecular diversity using a complexity-generating MCR-platform towards triazinane diones

B. Groenendaal, E. Ruijter, F. J. J. de Kanter, M. Lutz, A. L. Spek and R. V. A. Orru, Org. Biomol. Chem., 2008, 6, 3158 DOI: 10.1039/B807138A

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