Issue 13, 2008
From the journal:

Organic & Biomolecular Chemistry

Synthesis and solution thermodynamic study of rigidified and functionalised EGTA derivatives†

Lorenzo Tei,a   Zsolt Baranyai,b   Mauro Botta,a   Laura Piscopo,a   Silvio Aimeb  and  Giovanni B. Giovenzana*c  

* Corresponding authors

a Dipartimento di Scienze dell'Ambiente e della Vita, Università del Piemonte Orientale “Amedeo Avogadro”, Via Bellini 25/G, Alessandria, Italy

b Dipartimento di Chimica IFM, Università degli Studi di Torino, Via P. Giuria 7, Torino, Italy

c DiSCAFF & DFB Center, Università degli Studi del Piemonte Orientale “Amedeo Avogadro”, Via Bovio 6, Novara, Italy
E-mail: giovenzana@pharm.unipmn.it

Abstract

The synthesis of a new series of EGTA (ethyleneglycol-bis(2-aminoethylether)-N,N,N′,N′-tetraacetic acid) derivatives incorporating aromatic and functionalized aromatic moieties into the oxoethylenic bridge is described. A solution thermodynamic study was carried out to determine the influence of structural modifications on the coordinating ability towards lanthanide and alkaline earth metal ions. The presence of remote functional groups on the aromatic moiety would allow the conjugation of the complexes to macromolecules or other biological targets.

Graphical abstract: Synthesis and solution thermodynamic study of rigidified and functionalised EGTA derivatives

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Article information

DOI
https://doi.org/10.1039/B804195D
Article type
Paper
Submitted
11 Mar 2008
Accepted
28 Mar 2008
First published
30 Apr 2008

Org. Biomol. Chem., 2008,6, 2361-2368

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Synthesis and solution thermodynamic study of rigidified and functionalised EGTA derivatives

L. Tei, Z. Baranyai, M. Botta, L. Piscopo, S. Aime and G. B. Giovenzana, Org. Biomol. Chem., 2008, 6, 2361 DOI: 10.1039/B804195D

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