Issue 7, 2008

Highly enantioselective alkynylation of aldehydes catalyzed by a new oxazolidine–titanium complex

Abstract

The readily available and inexpensive new chiral oxazolidine 2a in combination with Ti(OiPr)4 was found to catalyze the reaction of an alkynylzinc reagent with various types of aldehydes to generate chiral propargylic alcohols with high enantioselectivities (up to 95%) and excellent yields (up to 98%).

Graphical abstract: Highly enantioselective alkynylation of aldehydes catalyzed by a new oxazolidine–titanium complex

Supplementary files

Article information

Article type
Paper
Submitted
20 Dec 2007
Accepted
30 Jan 2008
First published
22 Feb 2008

Org. Biomol. Chem., 2008,6, 1288-1292

Highly enantioselective alkynylation of aldehydes catalyzed by a new oxazolidine–titanium complex

Z. Xu, J. Mao and Y. Zhang, Org. Biomol. Chem., 2008, 6, 1288 DOI: 10.1039/B719624E

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements