Issue 6, 2008
From the journal:

Organic & Biomolecular Chemistry

Auxotrophic-precursor directed biosynthesis of nonribosomal lipopeptides with modified tryptophan residues†

Bagher Amir-Heidari,‡a   Jenny Thirlwaya  and  Jason Micklefield*a  

* Corresponding authors

a School of Chemistry and Manchester Interdisciplinary Biocentre, The University of Manchester, 131 Princess Street, Manchester, UK
E-mail: Jason.micklefield@manchester.ac.uk
Fax: +44 (0)161 306 8918
Tel: +44 (0)161 306 4509

Abstract

Feeding 5-hydroxy and 5-fluorotryptophan to a Streptomyces coelicolorTrp-auxotrophic strain WH101 results in the production of a number of new calcium-dependent antibiotics (CDAs) possessing modified Trp residues. It is anticipated that this method could be used to modulate the biological properties of Trp-containing nonribosomal peptide natural products, or to generate analogues with useful fluorescent properties for studying biological mechanisms of action.

Graphical abstract: Auxotrophic-precursor directed biosynthesis of nonribosomal lipopeptides with modified tryptophan residues

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Article information

DOI
https://doi.org/10.1039/B718766C
Article type
Communication
Submitted
04 Dec 2007
Accepted
18 Jan 2008
First published
11 Feb 2008

Org. Biomol. Chem., 2008,6, 975-978

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Auxotrophic-precursor directed biosynthesis of nonribosomal lipopeptides with modified tryptophan residues

B. Amir-Heidari, J. Thirlway and J. Micklefield, Org. Biomol. Chem., 2008, 6, 975 DOI: 10.1039/B718766C

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