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Issue 8, 2008
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Interactions of aluminium hydrolytic species with biomolecules

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In this contribution the formation of bioinorganic assemblies between the basic globular protein lysozyme and aqueous aluminium species including Al13-mer, Al30-mer and colloidal aluminium hydroxide have been explored and comparison made to previous interaction studies performed with bovine serum albumin (BSA). Specific charge-stabilised bioinorganic assemblies involving aluminium species and lysozyme were observed to form in contrast to the gel like structures formed on interaction of BSA with aluminium species. As demonstrated by infrared spectroscopy (structural assignment, 2D correlation spectroscopy), interactions mostly involve acidic surface groups of the proteins (Asp, Glu), with strong complexation and deprotonation in the case of BSA interacting with Al13 and Al30 and through hydrogen bonding for lysozyme interacting with the same species and aluminium hydroxide particles interacting with both biomolecules.

Graphical abstract: Interactions of aluminium hydrolytic species with biomolecules

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The article was received on 31 Mar 2008, accepted on 12 Jun 2008 and first published on 03 Jul 2008

Article type: Paper
DOI: 10.1039/B805406C
Citation: New J. Chem., 2008,32, 1346-1353

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    Interactions of aluminium hydrolytic species with biomolecules

    O. Deschaume, A. Fournier, K. L. Shafran and C. C. Perry, New J. Chem., 2008, 32, 1346
    DOI: 10.1039/B805406C

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