Issue 3, 2008
From the journal:

New Journal of Chemistry

Hydrolysis of insulin chain B using zirconium(iv) at neutral pH†

Sarah S. Cepedaa  and  Kathryn B. Grant*a  

* Corresponding authors

a Department of Chemistry, Center for Biotechnology and Drug Design, Georgia State University, P.O. Box 4098, Atlanta, GA 30302-4098, USA
E-mail: kbgrant@gsu.edu
Fax: +1-404-413-5505
Tel: +1-404-413-5522

Abstract

Zirconium(IV) hydrolyzes the 30-mer oligopeptide oxidized bovine insulin chain B after 4 h to 8 h of treatment at ∼pH 7.0 and 60 °C: MALDI-TOF and HPLC-ESI-MS and MS/MS data show significant levels of cleavage at Gly8-Ser9, Gly20-Glu21, Ser9-His10, Cys(SO3H)7-Gly8, and Cys(SO3H)19-Gly20 amide bonds within the oligopeptide.

Graphical abstract: Hydrolysis of insulin chain B using zirconium(iv) at neutral pH

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Article information

DOI
https://doi.org/10.1039/B715589A
Article type
Letter
Submitted
11 Oct 2007
Accepted
05 Feb 2008
First published
14 Feb 2008

New J. Chem., 2008,32, 388-391

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Hydrolysis of insulin chain B using zirconium(IV) at neutral pH

S. S. Cepeda and K. B. Grant, New J. Chem., 2008, 32, 388 DOI: 10.1039/B715589A

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