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Issue 12, 2008
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Microvortex for focusing, guiding and sorting of particles

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Abstract

We report a microvortex manipulator (MVM) that is a passive, scalable system with great potential for the manipulation and separation of particulate samples in microfluidic environments. The movement of particles is determined by a unique combination of helical flow, buoyant, and gravitational forces. Helical flows are induced by topographically patterned microchannel surfaces, which have previously been used for molecular mixing in microfluidic devices. We illustrate the mechanism of MVM and its applications in passive focusing of beads and cells into parallel streams and guiding of particles and cells. We also explore the application of the unique density-selectivity of microvortex focusing and successfully sort a mixture of two bead populations whose density difference is as small as 0.1 g cm−3.

Graphical abstract: Microvortex for focusing, guiding and sorting of particles

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Article information


Submitted
05 Aug 2008
Accepted
06 Oct 2008
First published
30 Oct 2008

Lab Chip, 2008,8, 2128-2134
Article type
Paper

Microvortex for focusing, guiding and sorting of particles

C. Hsu, D. Di Carlo, C. Chen, D. Irimia and M. Toner, Lab Chip, 2008, 8, 2128
DOI: 10.1039/B813434K

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