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Issue 10, 2008
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Long-term storable and shippable lipid bilayer membrane platform

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Abstract

The fragility and short lifetimes characteristic of conventionally formed lipid bilayer membranes has necessitated their preparation to be at the time and point of use. By using high freezing-point lipidsolvent mixtures, the process of lipid bilayer self-assembly may be reversibly arrested. In solid form, the bilayer precursor can be stored indefinitely and is sufficiently robust to withstand commercial shipping. Upon thawing, bilayer self-assembly resumes, resulting in a biologically functional membrane. Combination of this membrane precursor with an inexpensive chip results in a compact, practical, and disposable platform for ion channel measurements.

Graphical abstract: Long-term storable and shippable lipid bilayer membrane platform

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Article information


Submitted
09 May 2008
Accepted
16 Jul 2008
First published
22 Aug 2008

Lab Chip, 2008,8, 1742-1744
Article type
Technical Note

Long-term storable and shippable lipid bilayer membrane platform

T. Jeon, J. L. Poulos and J. J. Schmidt, Lab Chip, 2008, 8, 1742
DOI: 10.1039/B807932C

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