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Issue 8, 2008
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Soft lithography: masters on demand

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We report an ultra-rapid prototyping technique for forming microchannel networks for lab-on-a-chip applications, called masters on-demand. Channels are produced by replica molding on masters formed by laser printing on flexible copper printed circuit board (PCB) substrates. Masters of various designs and dimensions can be individually or mass produced in less than 10 minutes. Using this technique, we have fabricated channels as narrow as 100 μm with heights ranging between 9 μm and 70 μm. Multi-depth channel fabrication is also reported, using a two-step printing process. The functionality of devices formed in this manner is verified by performing in-channel electrophoretic separations and culture and analysis of primary mammalian cells.

Graphical abstract: Soft lithography: masters on demand

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The article was received on 10 Mar 2008, accepted on 21 May 2008 and first published on 24 Jun 2008

Article type: Technical Note
DOI: 10.1039/B804050H
Citation: Lab Chip, 2008,8, 1379-1385
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    Soft lithography: masters on demand

    M. Abdelgawad, M. W. L. Watson, E. W. K. Young, J. M. Mudrik, M. D. Ungrin and A. R. Wheeler, Lab Chip, 2008, 8, 1379
    DOI: 10.1039/B804050H

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