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Issue 8, 2008
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On-site manipulation of single chromosomal DNA molecules by using optically driven microstructures

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Abstract

We report a novel method for manipulation of single giant DNA molecules under a video microscope. Using optically driven microstructures, we manipulated chromosomal DNA of length in the order of millimetres, extended by electroosmotic flow without DNA breakage in aqueous solution: we picked up DNA, using microfabricated hooks and wound it around microfabricated bobbins.

Graphical abstract: On-site manipulation of single chromosomal DNA molecules by using optically driven microstructures

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Publication details

The article was received on 06 Mar 2008, accepted on 19 May 2008 and first published on 23 Jun 2008


Article type: Paper
DOI: 10.1039/B803753A
Lab Chip, 2008,8, 1280-1284

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    On-site manipulation of single chromosomal DNA molecules by using optically driven microstructures

    K. Terao, M. Washizu and H. Oana, Lab Chip, 2008, 8, 1280
    DOI: 10.1039/B803753A

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