Issue 6, 2008
From the journal:

Lab on a Chip

Protecting, patterning, and scaffolding supported lipid membranes using carbohydrate glasses†

Ann E. Oliver,*a   Eric L. Kendall,b   Michael C. Howland,b   Babak Sanii,a   Andrew P. Shrevec  and  Atul N. Parikh*abd  

* Corresponding authors

a Department of Applied Science, University of California-Davis, 1 Shields Ave., Davis, CA, USA
E-mail: aeoliver@ucdavis.edu
Fax: +1 530-752-2444
Tel: +1 530-754-9571

b Chemical Engineering and Materials Science, University of California-Davis, 1 Shields Ave., Davis, CA, USA

c Center for Integrated Nanotechnologies, Materials Physics and Applications Division, Los Alamos National Laboratory, Los Alamos, NM, USA

d Biophysics Graduate Group, University of California-Davis, 1 Shields Ave., Davis, CA, USA
E-mail: anparikh@ucdavis.edu
Fax: +1 530-752-2444
Tel: +1 530-754-7055

Abstract

Disaccharides are known to protect sensitive biomolecules against stresses caused by dehydration, both in vivo and in vitro. Here we demonstrate how interfacial accumulation of trehalose can be used to (1) produce rugged supported lipid bilayers capable of near total dehydration; (2) enable spatial patterning of membrane micro-arrays; and (3) form stable bilayers on otherwise lipophobic substrates (e.g., metal transducers) thus affording protecting, patterning, and scaffolding of lipid bilayers.

Graphical abstract: Protecting, patterning, and scaffolding supported lipid membranes using carbohydrate glasses

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DOI
https://doi.org/10.1039/B800370J
Article type
Paper
Submitted
10 Jan 2008
Accepted
13 Mar 2008
First published
11 Apr 2008

Lab Chip, 2008,8, 892-897

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Protecting, patterning, and scaffolding supported lipid membranes using carbohydrate glasses

A. E. Oliver, E. L. Kendall, M. C. Howland, B. Sanii, A. P. Shreve and A. N. Parikh, Lab Chip, 2008, 8, 892 DOI: 10.1039/B800370J

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