Jump to main content
Jump to site search

Issue 47, 2008
Previous Article Next Article

Preparation of polymer-coated mesoporous silica nanoparticles used for cellular imaging by a “graft-from” method

Author affiliations

Abstract

Multi-functional mesoporous silica nanoparticles (MSNs) coated with poly(N-isopropylacrylamide) (PNIPAM) composite nanomaterials have been designed and synthesized by atom transfer radical polymerization (ATRP) on the surface of MSN through the “grafting-from” approach. Such materials not only provide porous cores which can act as suitable reservoirs, but also possess thermosensitive polymer shells which can entrap hydrophilic guest molecules, like FITC, into the cores upon varying the temperature. The materials can easily carry guest molecules into human breast carcinoma cells (MCF-7) and show little cytotoxicity to the cells. It is demonstrated that such MSN@PNIPAM materials can be applied in biological systems for cellular imaging or as biosensors.

Graphical abstract: Preparation of polymer-coated mesoporous silica nanoparticles used for cellular imaging by a “graft-from” method

Back to tab navigation

Supplementary files

Publication details

The article was received on 08 Jul 2008, accepted on 18 Sep 2008 and first published on 29 Oct 2008


Article type: Paper
DOI: 10.1039/B811573G
Citation: J. Mater. Chem., 2008,18, 5731-5737

  •   Request permissions

    Preparation of polymer-coated mesoporous silica nanoparticles used for cellular imaging by a “graft-from” method

    Y. Yang, X. Yan, Y. Cui, Q. He, D. Li, A. Wang, J. Fei and J. Li, J. Mater. Chem., 2008, 18, 5731
    DOI: 10.1039/B811573G

Search articles by author

Spotlight

Advertisements