Issue 47, 2008

Preparation of polymer-coated mesoporous silicananoparticles used for cellular imaging by a “graft-from” method

Abstract

Multi-functional mesoporous silica nanoparticles (MSNs) coated with poly(N-isopropylacrylamide) (PNIPAM) composite nanomaterials have been designed and synthesized by atom transfer radical polymerization (ATRP) on the surface of MSN through the “grafting-from” approach. Such materials not only provide porous cores which can act as suitable reservoirs, but also possess thermosensitive polymer shells which can entrap hydrophilic guest molecules, like FITC, into the cores upon varying the temperature. The materials can easily carry guest molecules into human breast carcinoma cells (MCF-7) and show little cytotoxicity to the cells. It is demonstrated that such MSN@PNIPAM materials can be applied in biological systems for cellular imaging or as biosensors.

Graphical abstract: Preparation of polymer-coated mesoporous silica nanoparticles used for cellular imaging by a “graft-from” method

Supplementary files

Article information

Article type
Paper
Submitted
08 Jul 2008
Accepted
18 Sep 2008
First published
29 Oct 2008

J. Mater. Chem., 2008,18, 5731-5737

Preparation of polymer-coated mesoporous silica nanoparticles used for cellular imaging by a “graft-from” method

Y. Yang, X. Yan, Y. Cui, Q. He, D. Li, A. Wang, J. Fei and J. Li, J. Mater. Chem., 2008, 18, 5731 DOI: 10.1039/B811573G

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Spotlight

Advertisements