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Issue 11, 2008
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Protein-passivated Fe3O4nanoparticles: low toxicity and rapid heating for thermal therapy

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Abstract

Thermotherapy is a promising technique for the minimally invasive elimination of solid tumors. Here we report the fabrication of protein-coated iron oxide NPs (12 nm core) for use as thermal therapeutic agents. These albumin-passivated NPs are stable under physiological conditions, with rapid heating and cell killing capacity upon alternating magnetic field (AMF) exposure. The mode of action is specific: no measurable cytotoxicity was observed for the particle without AMF or for AMF exposure without the particle.

Graphical abstract: Protein-passivated Fe3O4nanoparticles: low toxicity and rapid heating for thermal therapy

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Publication details

The article was received on 04 Dec 2007, accepted on 23 Jan 2008 and first published on 19 Feb 2008


Article type: Paper
DOI: 10.1039/B718745A
Citation: J. Mater. Chem., 2008,18, 1204-1208
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    Protein-passivated Fe3O4nanoparticles: low toxicity and rapid heating for thermal therapy

    B. Samanta, H. Yan, N. O. Fischer, J. Shi, D. J. Jerry and V. M. Rotello, J. Mater. Chem., 2008, 18, 1204
    DOI: 10.1039/B718745A

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