Issue 48, 2008
From the journal:

Journal of Materials Chemistry

Bacterial magnetic nanoparticles as drug carriers

Lin Guo,*a   Ji Huang,b   Xin Zhang,a   Ying Lic  and  Limin Zhengb  

* Corresponding authors

a Key Laboratory of Mesoscopic Chemistry of MOE and School of Chemistry and Chemical Engineering, Nanjing University, Nanjing University, Nanjing, P. R. China
E-mail: linguo@nju.edu.cn.
Fax: +86 25 83317761
Tel: +86 25 83592369

b State Key Laboratory of Coordination Chemistry, Nanjing University, Nanjing, P. R. China

c State Key Laboratories for Agro-biotechnology and College of Biological Sciences, China Agricultural University, Beijing, P. R. China

Abstract

Magnet doxorubicin (DOX) drugs are efficiently produced by using bacterial magnetic nanoparticles (BMP) as anti-cancer drug carriers and dual functional cross-linkers glutaraldehyde, disuccinimidyl (DSS), N-succinimidyl 3-(2-pyridyldithio) propionate (SPDP) and di(N-succinimidyl) carbonate (DSC) as coupling reagents. Glutaraldehyde shows the highest coupling efficiency with the DOX load ratio of about 46.6%. Doxorubicin coupled bacterial magnetic nanoparticles (DBMP) disperse well in aqueous solution, exhibit a narrow size distribution with mean diameter about 70 nm and a high magnetic response with ferromagnetic properties, and show strong cytotoxicity to HePG2 and MCF-7 cancer cells.

Graphical abstract: Bacterial magnetic nanoparticles as drug carriers

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Article information

DOI
https://doi.org/10.1039/B808556K
Article type
Paper
Submitted
20 May 2008
Accepted
10 Sep 2008
First published
13 Nov 2008

J. Mater. Chem., 2008,18, 5993-5997

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Bacterial magnetic nanoparticles as drug carriers

L. Guo, Ji Huang, X. Zhang, Y. Li and L. Zheng, J. Mater. Chem., 2008, 18, 5993 DOI: 10.1039/B808556K

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