Issue 4, 2008

Quick and highly efficient copper-catalyzed cycloaddition of aliphatic and aryl azides with terminal alkynes “on water”

Abstract

We have developed a quick and highly efficient method for copper-catalyzed cycloaddition of water-insoluble aliphatic/aryl azides and alkynes “on water” at room temperature, the protocol uses 10 mol% CuBr as the catalyst, and 50 mol% PhSMe as the ligand.

Graphical abstract: Quick and highly efficient copper-catalyzed cycloaddition of aliphatic and aryl azides with terminal alkynes “on water”

Article information

Article type
Paper
Submitted
21 Nov 2007
Accepted
16 Jan 2008
First published
25 Feb 2008

Green Chem., 2008,10, 452-456

Quick and highly efficient copper-catalyzed cycloaddition of aliphatic and aryl azides with terminal alkynes “on water

F. Wang, H. Fu, Y. Jiang and Y. Zhao, Green Chem., 2008, 10, 452 DOI: 10.1039/B718051A

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