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Issue 8, 2008
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Characterization of products formed in the reaction of ozone with α-pinene: case for organic peroxides

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Abstract

The generation of reactive oxygen species (ROS) and their subsequent induced pulmonary and systemic oxidative stress has been implicated as an important molecular mechanism of PM-mediated toxicity. However, recent work has shown that there is significant ROS associated with ambient PM. In order to understand the formation mechanisms as well as understand the potential health effects of particle-bound oxidative species, the α-pinene–O3oxidation chemical system was studied to elucidate the structures of reaction products using liquid chromatography-multiple stage mass spectrometry (LC-MSn). The classes of compounds identified based on their multiple stage-MS fragmentation patterns, mechanistic considerations of α-pinene–O3oxidation, and general fragmentation rules, of the products from this reaction system were highly oxygenated species, predominantly containing hydroperoxide and peroxide functional groups. The oxidant species observed were clearly stable for the 1–3 h that elapsed during aerosol collection and analysis, and probably for much longer, thus rendering it possible for these species to bind onto particles forming fine particulate organic peroxides that concentrate on the particles and could deliver concentrated doses of ROS in vivo to tissue.

Graphical abstract: Characterization of products formed in the reaction of ozone with α-pinene: case for organic peroxides

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Article information


Submitted
13 Mar 2008
Accepted
02 Jun 2008
First published
04 Jul 2008

J. Environ. Monit., 2008,10, 966-974
Article type
Paper

Characterization of products formed in the reaction of ozone with α-pinene: case for organic peroxides

P. Venkatachari and P. K. Hopke, J. Environ. Monit., 2008, 10, 966
DOI: 10.1039/B804357D

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