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Issue 2, 2008
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Fluorine in medicinal chemistry

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Abstract

It has become evident that fluorinated compounds have a remarkable record in medicinal chemistry and will play a continuing role in providing lead compounds for therapeutic applications. This tutorial review provides a sampling of renowned fluorinated drugs and their mode of action with a discussion clarifying the role and impact of fluorine substitution on drug potency.

Graphical abstract: Fluorine in medicinal chemistry

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Article information


Submitted
26 Nov 2007
First published
13 Dec 2007

Chem. Soc. Rev., 2008,37, 320-330
Article type
Tutorial Review

Fluorine in medicinal chemistry

S. Purser, P. R. Moore, S. Swallow and V. Gouverneur, Chem. Soc. Rev., 2008, 37, 320
DOI: 10.1039/B610213C

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