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Issue 16, 2008
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Tuning the dynamics and molecular distribution of the self-spreading lipid bilayer

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Abstract

The self-spreading dynamics of lipid bilayers were investigated at controlled electrolyte concentrations. The self-spreading velocity increased when the concentration of NaCl was increased from 1 to 100 mM. Comparing the experimentally determined spreading energy with that estimated from theoretical models, we found that the self-spreading dynamics were well explained by considering the van der Waals interaction, double layer interaction and hydration interaction energies between the self-spreading bilayer and the substrate. The characteristic behavior at high concentration is attributable to the increase in the density of the lipid layer, originating from the effective shielding of the molecular charges by the electrolyte ions in solution. The distribution of doped dye-labeled molecule within the spreading bilayer was also controllable by tuning the electrolyte concentration. All of these findings were explained by systematic changes in bilayer–substrate or inter-molecular interactions depending on the electrolyte concentration.

Graphical abstract: Tuning the dynamics and molecular distribution of the self-spreading lipid bilayer

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Publication details

The article was received on 16 Oct 2007, accepted on 01 Feb 2008 and first published on 03 Mar 2008


Article type: Paper
DOI: 10.1039/B715983H
Phys. Chem. Chem. Phys., 2008,10, 2243-2248

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    Tuning the dynamics and molecular distribution of the self-spreading lipid bilayer

    H. Nabika, A. Fukasawa and K. Murakoshi, Phys. Chem. Chem. Phys., 2008, 10, 2243
    DOI: 10.1039/B715983H

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