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Issue 7, 2008
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Screening strategies based on solubility and solution composition generate pharmaceutically acceptable cocrystals of carbamazepine

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Abstract

Four different screening techniques were used to form cocrystals of carbamazepine containing pharmaceutically acceptable carboxylic acids. Twenty-seven unique solid phases utilizing eighteen carboxylic acid coformers were generated in the screening experiments. Cocrystal formation and stability in water is reported. Phase solubility diagrams and triangular phase diagrams are used to illustrate how saturation of the reactants leads to supersaturation of the cocrystal.

Graphical abstract: Screening strategies based on solubility and solution composition generate pharmaceutically acceptable cocrystals of carbamazepine

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Article information


Submitted
08 Oct 2007
Accepted
21 Feb 2008
First published
20 Mar 2008

CrystEngComm, 2008,10, 856-864
Article type
Paper

Screening strategies based on solubility and solution composition generate pharmaceutically acceptable cocrystals of carbamazepine

S. L. Childs, N. Rodríguez-Hornedo, L. S. Reddy, A. Jayasankar, C. Maheshwari, L. McCausland, R. Shipplett and B. C. Stahly, CrystEngComm, 2008, 10, 856
DOI: 10.1039/B715396A

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