Issue 3, 2008
From the journal:

CrystEngComm

Crystalline forms and aqueous solubilities of an IBSdrug, tegaserod†‡§

R. Srivijaya,a   Peddy Vishweshwar,*a   B. R. Sreekantha  and  K. Vyas*a  

* Corresponding authors

a Department of Analytical Research, Discovery Research, Dr. Reddy's Laboratories Ltd., Miyapur, Hyderabad, India
E-mail: vishweshwarp@drreddys.com, vyask@drreddys.com
Fax: 91 040 23045440
Tel: 91 040 23045439

Abstract

Tegaserod is shown to exist in the tautomeric form II in the free base and also in a monohydrate. The Tegaserod nicotinate salt has a 6-fold better aqueous solubility than the marketed Tegaserod maleate (form A, Zelnorm™).

Graphical abstract: Crystalline forms and aqueous solubilities of an IBS drug, tegaserod

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Article information

DOI
https://doi.org/10.1039/B714374P
Article type
Communication
Submitted
17 Sep 2007
Accepted
19 Sep 2007
First published
05 Oct 2007

CrystEngComm, 2008,10, 283-287

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Crystalline forms and aqueous solubilities of an IBS drug, tegaserod

R. Srivijaya, P. Vishweshwar, B. R. Sreekanth and K. Vyas, CrystEngComm, 2008, 10, 283 DOI: 10.1039/B714374P

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