Issue 3, 2008

Crystalline forms and aqueous solubilities of an IBSdrug, tegaserod§

Abstract

Tegaserod is shown to exist in the tautomeric form II in the free base and also in a monohydrate. The Tegaserod nicotinate salt has a 6-fold better aqueous solubility than the marketed Tegaserod maleate (form A, Zelnorm).

Graphical abstract: Crystalline forms and aqueous solubilities of an IBS drug, tegaserod

Supplementary files

Article information

Article type
Communication
Submitted
17 Sep 2007
Accepted
19 Sep 2007
First published
05 Oct 2007

CrystEngComm, 2008,10, 283-287

Crystalline forms and aqueous solubilities of an IBS drug, tegaserod

R. Srivijaya, P. Vishweshwar, B. R. Sreekanth and K. Vyas, CrystEngComm, 2008, 10, 283 DOI: 10.1039/B714374P

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