Issue 44, 2008
From the journal:

Chemical Communications

Modular synthesis of multivalent glycoarchitectures and their unique selectin binding behavior†

Ilona Papp,a   Jens Dernedde,b   Sven Endersb  and  Rainer Haag*a  

* Corresponding authors

a Freie Universität Berlin, Institut für Chemie und Biochemie, Takustrasse 3, Berlin, Germany
E-mail: haag@chemie.fu-berlin.de
Fax: +49 30 838 53357
Tel: +49 30 838 52633

b Universitätsklinikum Charité Berlin, Zentralinstitut für Laboratoriumsmedizin und Pathobiochemie, CBF Hindenburgdamm 30, Berlin
Fax: +49 30 844 54152
Tel: + 49 30 844 54639

Abstract

Hyperbranched polyglycerols (HPGs) are ideal scaffolds for the multivalent presentation of saccharides, due to their biocompatible, carbohydrate-like properties; here, we report the conjugation of galactose sugar moieties to HPG, and the multivalent effect of these constructs on selectin binding.

Graphical abstract: Modular synthesis of multivalent glycoarchitectures and their unique selectin binding behavior

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Article information

DOI
https://doi.org/10.1039/B813414F
Article type
Communication
Submitted
01 Aug 2008
Accepted
11 Sep 2008
First published
03 Oct 2008

Chem. Commun., 2008, 5851-5853

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Modular synthesis of multivalent glycoarchitectures and their unique selectin binding behavior

I. Papp, J. Dernedde, S. Enders and R. Haag, Chem. Commun., 2008, 5851 DOI: 10.1039/B813414F

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