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Issue 39, 2008
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A catalytic highly enantioselective direct synthesis of 2-bromo-2-nitroalkan-1-ols through a Henry reaction

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Abstract

Highly enantiomerically enriched 2-bromo-2-nitroalkan-1-ols are prepared by direct condensation of aliphatic and aromatic aldehydes with bromonitromethane in the presence of a catalytic amount of copper(II) acetate and a C1-symmetric camphor-derived amino pyridine ligand.

Graphical abstract: A catalytic highly enantioselective direct synthesis of 2-bromo-2-nitroalkan-1-ols through a Henry reaction

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Publication details

The article was received on 10 Jun 2008, accepted on 10 Jul 2008 and first published on 29 Aug 2008


Article type: Communication
DOI: 10.1039/B809739A
Citation: Chem. Commun., 2008,0, 4840-4842

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    A catalytic highly enantioselective direct synthesis of 2-bromo-2-nitroalkan-1-ols through a Henry reaction

    G. Blay, V. Hernández-Olmos and J. R. Pedro, Chem. Commun., 2008, 0, 4840
    DOI: 10.1039/B809739A

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