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Issue 36, 2008
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Enantioselective organocatalyzed Henry reaction with fluoromethyl ketones

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Abstract

Remarkable generality in scope of new C9-benzoylcupreines bearing electron-withdrawing substituents for the nitroaldol condensation with fluoromethyl ketones is presented. Both tri- and difluoromethyl ketones provided excellent levels of stereoinduction (ee 76–99%) under mild reaction conditions and low loading of catalyst (1–5 mol%).

Graphical abstract: Enantioselective organocatalyzed Henry reaction with fluoromethyl ketones

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Publication details

The article was received on 06 May 2008, accepted on 04 Jun 2008 and first published on 24 Jul 2008


Article type: Communication
DOI: 10.1039/B807640E
Citation: Chem. Commun., 2008,0, 4360-4362

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    Enantioselective organocatalyzed Henry reaction with fluoromethyl ketones

    M. Bandini, R. Sinisi and A. Umani-Ronchi, Chem. Commun., 2008, 0, 4360
    DOI: 10.1039/B807640E

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