Jump to main content
Jump to site search

Issue 36, 2008
Previous Article Next Article

Lewis base-catalyzed conjugate reduction and reductive aldol reaction of α,β-unsaturated ketones using trichlorosilane

Author affiliations

Abstract

Lewis bases such as Ph3P[double bond, length as m-dash]O and HMPA catalyze the 1,4-reduction of α,β-unsaturated ketones with trichlorosilane, and because the 1,2-reduction of aldehydes scarcely proceeded under the conditions, one-pot reductive aldol reactions with aldehydes were successfully achieved; preliminary studies using a chiral Lewis base revealed a high potential for enantioselective catalysis.

Graphical abstract: Lewis base-catalyzed conjugate reduction and reductive aldol reaction of α,β-unsaturated ketones using trichlorosilane

Back to tab navigation

Supplementary files

Publication details

The article was received on 02 May 2008, accepted on 03 Jun 2008 and first published on 17 Jul 2008


Article type: Communication
DOI: 10.1039/B807529H
Citation: Chem. Commun., 2008,0, 4309-4311

  •   Request permissions

    Lewis base-catalyzed conjugate reduction and reductive aldol reaction of α,β-unsaturated ketones using trichlorosilane

    M. Sugiura, N. Sato, S. Kotani and M. Nakajima, Chem. Commun., 2008, 0, 4309
    DOI: 10.1039/B807529H

Search articles by author

Spotlight

Advertisements