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Issue 36, 2008
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Chemoenzymatic synthesis of GDP-azidodeoxymannoses: non-radioactive probes for mannosyltransferase activity

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Abstract

GDP-2-, 3-, 4- or 6-azidomannoses can be successfully prepared from the corresponding azidomannose-1-phosphates and GTP using the enzyme GDP-Mannosepyrophosphorylase (GDP-ManPP) from Salmonella enterica and may serve as useful probes for mannosyltransferase activity.

Graphical abstract: Chemoenzymatic synthesis of GDP-azidodeoxymannoses: non-radioactive probes for mannosyltransferase activity

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Publication details

The article was received on 25 Apr 2008, accepted on 02 Jun 2008 and first published on 18 Jul 2008


Article type: Communication
DOI: 10.1039/B807016D
Citation: Chem. Commun., 2008,0, 4321-4323

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    Chemoenzymatic synthesis of GDP-azidodeoxymannoses: non-radioactive probes for mannosyltransferase activity

    S. Marchesan and D. Macmillan, Chem. Commun., 2008, 0, 4321
    DOI: 10.1039/B807016D

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