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Issue 38, 2008
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Highly enantioselective organocatalytic formation of a quaternary carbon center via chiral Brønsted acid catalyzed self-coupling of enamides

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Abstract

The enantioselective BINOL-phosphate catalyzed formation of a quaternary carbon center, bearing a N-atom has been achieved through the self-coupling reaction of enamides; the corresponding products have been isolated in up to >99% ee and their application for the synthesis of versatile synthetic building blocks—β-aminoketones—has been demonstrated.

Graphical abstract: Highly enantioselective organocatalytic formation of a quaternary carbon center via chiral Brønsted acid catalyzed self-coupling of enamides

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Publication details

The article was received on 17 Mar 2008, accepted on 27 Jun 2008 and first published on 05 Aug 2008


Article type: Communication
DOI: 10.1039/B804477E
Citation: Chem. Commun., 2008,0, 4637-4639

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    Highly enantioselective organocatalytic formation of a quaternary carbon center via chiral Brønsted acid catalyzed self-coupling of enamides

    C. Baudequin, A. Zamfir and S. B. Tsogoeva, Chem. Commun., 2008, 0, 4637
    DOI: 10.1039/B804477E

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