Recent advances in chiral phosphine–silver(i) complex-catalyzed asymmetric reactions

Abstract

Since the first report of silver(I)-catalyzed asymmetric aldol-type reaction of activated isocyanides with aldehydes using a chiral ferrocenylphosphine as a chiral phosphine ligand has been appeared in 1990, various chiral phosphine–silver(I) catalysts have been utilized in asymmetric transformations. This feature articles describes recent examples of chiral phosphine–silver(I) complex-catalyzed asymmetric reactions such as allylation, aldol reaction, Mannich-type reaction, hetero-Diels–Alder reaction, 1,3-dipolar cycloaddition and nitroso aldol reaction.