Issue 47, 2008

Asymmetric organocatalytic Michael addition of ketones to vinylsulfone

Abstract

Highly enantioselective organocatalytic Michael addition of ketones to vinylsulfone catalyzed by a cinchona alkaloid-derived primary amine is reported for the first time; the described synthetic methodology was applied to the synthesis of sodium cyclamate.

Graphical abstract: Asymmetric organocatalytic Michael addition of ketones to vinylsulfone

Supplementary files

Article information

Article type
Communication
Submitted
17 Sep 2008
Accepted
10 Oct 2008
First published
05 Nov 2008

Chem. Commun., 2008, 6315-6317

Asymmetric organocatalytic Michael addition of ketones to vinylsulfone

Q. Zhu, L. Cheng and Y. Lu, Chem. Commun., 2008, 6315 DOI: 10.1039/B816307C

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