Efficient mono- and bis-functionalization of 3,6-dichloropyridazine using (tmp)2Zn·2MgCl2·2LiCl

Stefan Wunderlich; Paul Knochel

doi:10.1039/B815903C

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Efficient mono- and bis-functionalization of 3,6-dichloropyridazine using (tmp)₂Zn·2MgCl₂·2LiCl†

Stefan Wunderlich^a and Paul Knochel*^a

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* Corresponding authors

^a Department Chemie, Ludwig-Maximilians-Universität München, Butenandstr. 5-13, Haus F, München, Germany
E-mail: Paul.Knochel@cup.uni-muenchen.de
Fax: (+49)-89-2180-77680
Tel: (+49)-2180-77681

Abstract

3,6-Dichloropyridazine undergoes a smooth metallation using (tmp)₂Zn·2MgCl₂·2LiCl. The resulting bis-organozinc species react with various electrophiles; subsequent functionalization via a second metallation proceeds readily; further reactions with hydrazine lead to highly substituted pyrazolo[3,4-c]pyridazines derivatives.

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Supplementary files

Experimental section and spectroscopic data PDF (969K)

Article information

DOI: https://doi.org/10.1039/B815903C
Article type: Communication
Submitted: 11 Sep 2008
Accepted: 06 Oct 2008
First published: 04 Nov 2008

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Chem. Commun., 2008, 6387-6389

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Efficient mono- and bis-functionalization of 3,6-dichloropyridazine using (tmp)₂Zn·2MgCl₂·2LiCl

S. Wunderlich and P. Knochel, Chem. Commun., 2008, 6387 DOI: 10.1039/B815903C

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