Issue 47, 2008
From the journal:

Chemical Communications

Evaluation of aspirinmetabolites as inhibitors of hypoxia-inducible factor hydroxylases†

Benoit M. Lienard,a   Ana Conejo-García,a   Ineke Stolze,b   Christoph Loenarz,a   Neil J. Oldham,‡a   Peter J. Ratcliffeb  and  Christopher J. Schofield*a  

* Corresponding authors

a The Department of Chemistry and the Oxford Centre for Integrative Systems Biology, Chemistry Research Laboratory, University of Oxford, Mansfield Road, Oxford, United Kingdom
E-mail: christopher.schofield@chemistry.oxford.ac.uk
Fax: +44 (0) 1865 275674
Tel: +44 (0) 1865 275625

b Henry Wellcome Building for Molecular Physiology, University of Oxford, Oxford, United Kingdom

Abstract

Known and potential aspirinmetabolites were evaluated as inhibitors of oxygen-sensing hypoxia-inducible transcription factor (HIF) hydroxylases; some of the metabolites were found to stabilise HIF-α in cells.

Graphical abstract: Evaluation of aspirinmetabolites as inhibitors of hypoxia-inducible factor hydroxylases

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Article information

DOI
https://doi.org/10.1039/B814440K
Article type
Communication
Submitted
19 Aug 2008
Accepted
09 Oct 2008
First published
05 Nov 2008

Chem. Commun., 2008, 6393-6395

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Evaluation of aspirinmetabolites as inhibitors of hypoxia-inducible factor hydroxylases

B. M. Lienard, A. Conejo-García, I. Stolze, C. Loenarz, N. J. Oldham, P. J. Ratcliffe and C. J. Schofield, Chem. Commun., 2008, 6393 DOI: 10.1039/B814440K

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