Issue 40, 2008
From the journal:

Chemical Communications

Identification of an anti-MRSA dihydrofolate reductase inhibitor from a diversity-oriented synthesis†

Emma E. Wyatt,a   Warren R. J. D. Galloway,a   Gemma L. Thomas,a   Martin Welch,b   Olivier Loiseleur,c   Alleyn T. Plowrightd  and  David R. Spring*a  

* Corresponding authors

a Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge, UK
E-mail: drspring@ch.cam.ac.uk
Fax: +44 (0) 1223-336362
Tel: +44 (0) 1223-336498

b Department of Biochemistry, University of Cambridge, Cambridge, UK

c Syngenta Crop Production AG, Schwarzwaldallee 215, 4002 Basel, Switzerland

d AstraZeneca, Pepparedsleden 1, Mölndal, Sweden

Abstract

The screening of a diversity-oriented synthesis library followed by structure–activity relationship investigations have led to the discovery of an anti-MRSA agent which operates as an inhibitor of Staphylococcus aureusdihydrofolate reductase.

Graphical abstract: Identification of an anti-MRSA dihydrofolate reductase inhibitor from a diversity-oriented synthesis

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Article information

DOI
https://doi.org/10.1039/B812901K
Article type
Communication
Submitted
25 Jul 2008
Accepted
12 Aug 2008
First published
10 Sep 2008

Chem. Commun., 2008, 4962-4964

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Identification of an anti-MRSA dihydrofolate reductase inhibitor from a diversity-oriented synthesis

E. E. Wyatt, W. R. J. D. Galloway, G. L. Thomas, M. Welch, O. Loiseleur, A. T. Plowright and D. R. Spring, Chem. Commun., 2008, 4962 DOI: 10.1039/B812901K

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