Issue 40, 2008
From the journal:

Chemical Communications

Phosphine-catalyzed annulation of ethyl (arylimino)acetates: synthesis of highly functionalized oxoimidazolidines†

Guang-Ning Ma,a   Fei-Jun Wang,a   Jun Gaob  and  Min Shi*ab  

* Corresponding authors

a School of Chemistry & Molecular Engineering, East China University of Science and Technology, Laboratory for Advanced Materials and Institute of Fine Chemicals, 130 Mei Long Road, Shanghai 200237, China

b State Key Laboratory of Organometallic Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 354 Fenglin Lu, Shanghai 200032, China
E-mail: Mshi@mail.sioc.ac.cn
Fax: +86-21-64166128

Abstract

This paper describes an unexpected and novel nucleophilic phosphine-catalyzed annulation of ethyl (arylimino)acetates to give polysubstituted oxoimidazolidine derivatives in moderate to good yields from simple and easily available starting materials under mild conditions. In this reaction, the addition of methyl vinyl ketone (MVK) is essential to induce the formation of oxoimidazolidines.

Graphical abstract: Phosphine-catalyzed annulation of ethyl (arylimino)acetates: synthesis of highly functionalized oxoimidazolidines

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Article information

DOI
https://doi.org/10.1039/B811167G
Article type
Communication
Submitted
01 Jul 2008
Accepted
05 Aug 2008
First published
18 Sep 2008

Chem. Commun., 2008, 4998-5000

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Phosphine-catalyzed annulation of ethyl (arylimino)acetates: synthesis of highly functionalized oxoimidazolidines

G. Ma, F. Wang, J. Gao and M. Shi, Chem. Commun., 2008, 4998 DOI: 10.1039/B811167G

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