A robust strategy for the preparation of libraries of metallopeptides. A new paradigm for the discovery of targeted molecular imaging and therapy agents

Andrea F. Armstrong; Nick Oakley; Shannon Parker; Patrick W. Causey; Jennifer Lemon; Alfredo Capretta; Craig Zimmerman; John Joyal; Francis Appoh; Jon Zubieta; John W. Babich; Gurmit Singh; John F. Valliant

doi:10.1039/B810706H

A robust strategy for the preparation of libraries of metallopeptides. A new paradigm for the discovery of targeted molecular imaging and therapy agents†

Andrea F. Armstrong,^a Nick Oakley,^a Shannon Parker,^a Patrick W. Causey,^a Jennifer Lemon,^a Alfredo Capretta,^a Craig Zimmerman,^b John Joyal,^b Francis Appoh,^a Jon Zubieta,^c John W. Babich,^b Gurmit Singh^a and John F. Valliant*^a

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^a Departments of Chemistry and Medical Physics and Applied Radiation Sciences, McMaster University, Hamilton, ON, Canada
E-mail: valliant@mcmaster.ca
Fax: 905-522-7776
Tel: 905-525-9140 ext. 22840

^b Molecular Insight Pharmaceuticals Inc., Cambridge, USA

^c Department of Chemistry, Syracuse University, Syracuse, USA

Abstract

A robust method for synthesizing structurally diverse metallopeptide libraries using a Re(I) complex of a non-natural amino acid was developed as a way to accelerate the discovery of novel molecular imaging probes.

Chemical Communications

A robust strategy for the preparation of libraries of metallopeptides. A new paradigm for the discovery of targeted molecular imaging and therapy agents†

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A robust strategy for the preparation of libraries of metallopeptides. A new paradigm for the discovery of targeted molecular imaging and therapy agents

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