Issue 39, 2008
From the journal:

Chemical Communications

A catalytic highly enantioselective direct synthesis of 2-bromo-2-nitroalkan-1-ols through a Henry reaction†

Gonzalo Blay,*a   Victor Hernández-Olmosa  and  José R. Pedro*a  

* Corresponding authors

a Departament de Química Orgànica, Facultat de Química, Universitat de València, Dr Moliner 50, Burjassot (València), Spain
E-mail: jose.r.pedro@uv.es; gonzalo.blay@uv.es
Fax: +34 963544328
Tel: +34 963544336

Abstract

Highly enantiomerically enriched 2-bromo-2-nitroalkan-1-ols are prepared by direct condensation of aliphatic and aromatic aldehydes with bromonitromethane in the presence of a catalytic amount of copper(II) acetate and a C1-symmetric camphor-derived amino pyridine ligand.

Graphical abstract: A catalytic highly enantioselective direct synthesis of 2-bromo-2-nitroalkan-1-ols through a Henry reaction

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Article information

DOI
https://doi.org/10.1039/B809739A
Article type
Communication
Submitted
10 Jun 2008
Accepted
10 Jul 2008
First published
29 Aug 2008

Chem. Commun., 2008, 4840-4842

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A catalytic highly enantioselective direct synthesis of 2-bromo-2-nitroalkan-1-ols through a Henry reaction

G. Blay, V. Hernández-Olmos and J. R. Pedro, Chem. Commun., 2008, 4840 DOI: 10.1039/B809739A

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