Issue 45, 2008
From the journal:

Chemical Communications

Unprecedented biological cyclopropanation in the biosynthesis of FR-900848†

Tetsuo Tokiwano,*b   Hiroaki Watanabe,a   Takashi Seoa  and  Hideaki Oikawa*a  

* Corresponding authors

a Division of Chemistry, Graduate School of Science, Hokkaido University, Sapporo, Japan
E-mail: hoik@sci.hokudai.ac.jp

b Department of Biotechnology, Faculty of Bioresource Sciences, Akita Prefectural University, Akita, Japan
E-mail: tkwn@akita-pu.ac.jp

Abstract

We were able to show the predominant incorporation of a single enantiomer and intact incorporation of multiply labelled synthetic diketide precursors (14 and 16), which established the intermediacy of cyclopropanated diketide and led to our proposal for the unprecedented biological cyclopropanation, viaPKS (polyketide synthase) having a novel cyclopropanase domain, in the biosynthesis of FR-900848 (1).

Graphical abstract: Unprecedented biological cyclopropanation in the biosynthesis of FR-900848

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Article information

DOI
https://doi.org/10.1039/B809610D
Article type
Communication
Submitted
06 Jun 2008
Accepted
12 Sep 2008
First published
14 Oct 2008

Chem. Commun., 2008, 6016-6018

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Unprecedented biological cyclopropanation in the biosynthesis of FR-900848

T. Tokiwano, H. Watanabe, T. Seo and H. Oikawa, Chem. Commun., 2008, 6016 DOI: 10.1039/B809610D

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