Activation of organozinc reagents with t-Bu-P4 base for transition metal-free catalytic SN2′ reaction

Abstract

The t-Bu-P4 base was found to be an excellent catalyst for activating organozinc reagents and was used to promote the S_N2′ reaction of α,β-unsaturated esters bearing a γ-chloride using various organozinc reagents: these reactions proceeded in high yields with excellent chemo-and regioselectivity.