Issue 35, 2008

Lactonizations of carboxylic acid-substituted 3-fluorodihydropyridines with electrophiles: peculiar behaviour of F+

Abstract

Whereas for 3-fluorodihydropyridine-substituted carboxylic acids electrophiles such as HCl, iodine, bromine and peracids discriminate the double bond lacking and that bearing fluorine, no such differentiation took place in the case of electrophilic fluorine since the formation of both mono and gem-difluorolactones took place.

Graphical abstract: Lactonizations of carboxylic acid-substituted 3-fluorodihydropyridines with electrophiles: peculiar behaviour of F+

Supplementary files

Article information

Article type
Communication
Submitted
28 Apr 2008
Accepted
23 May 2008
First published
08 Jul 2008

Chem. Commun., 2008, 4150-4152

Lactonizations of carboxylic acid-substituted 3-fluorodihydropyridines with electrophiles: peculiar behaviour of F+

H. Rudler, A. Parlier, L. Hamon, P. Herson and J. Daran, Chem. Commun., 2008, 4150 DOI: 10.1039/B807092J

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