Issue 34, 2008
From the journal:

Chemical Communications

Target-driven selection in a dynamic nitrone library†

Simon M. Turega,a   Christiane Lorenz,a   Jan W. Sadownika  and  Douglas Philp*a  

* Corresponding authors

a EaStCHEM and Centre for Biomolecular Sciences, School of Chemistry, University of St Andrews, St Andrews, Fife, UK
E-mail: d.philp@st-andrews.ac.uk
Fax: +44 1334 463808
Tel: +44 1334 467264

Abstract

Nitrones undergo dynamic exchange in chloroform at room temperature through two mechanisms—hydrolysis and recombination or hydroxylamine addition/elimination; this dynamic exchange is harnessed to select a nitrone-based bis(amidopyridine) receptor for diacids from a group of four nitrones through its binding to a glutaric acid-based target.

Graphical abstract: Target-driven selection in a dynamic nitrone library

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Article information

DOI
https://doi.org/10.1039/B805945D
Article type
Communication
Submitted
08 Apr 2008
Accepted
16 May 2008
First published
03 Jul 2008

Chem. Commun., 2008, 4076-4078

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Target-driven selection in a dynamic nitrone library

S. M. Turega, C. Lorenz, J. W. Sadownik and D. Philp, Chem. Commun., 2008, 4076 DOI: 10.1039/B805945D

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