Issue 9, 2008
From the journal:

Chemical Communications

Trimethylaluminium mediated amide bond formation in a continuous flow microreactor as key to the synthesis of rimonabant and efaproxiral†

Tomas Gustafsson,a   Fritiof Ponténb  and  Peter H. Seeberger*a  

* Corresponding authors

a Laboratory for Organic Chemistry, Swiss Federal Institute of Technology (ETH) Zürich, Wolfgang-Pauli-Strasse 10, 8093 Zürich, Switzerland
E-mail: seeberger@org.chem.ethz.ch
Fax: +41 1 633 1235
Tel: +41 1 633 2103

b AstraZeneca R&D Mölndal, 431 83 Mölndal, Sweden

Abstract

A safe, functional-group-tolerant and high-throughput version of the trimethylaluminium mediated amide bond formation reaction has been developed in a microreactor system; rimonabant and efaproxiral were prepared to illustrate the utility of the method.

Graphical abstract: Trimethylaluminium mediated amide bond formation in a continuous flow microreactor as key to the synthesis of rimonabant and efaproxiral

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Article information

DOI
https://doi.org/10.1039/B719603B
Article type
Communication
Submitted
19 Dec 2007
Accepted
16 Jan 2008
First published
01 Feb 2008

Chem. Commun., 2008, 1100-1102

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Trimethylaluminium mediated amide bond formation in a continuous flow microreactor as key to the synthesis of rimonabant and efaproxiral

T. Gustafsson, F. Pontén and P. H. Seeberger, Chem. Commun., 2008, 1100 DOI: 10.1039/B719603B

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