Issue 4, 2008

A cleavable linker strategy for optimising enolate alkylation reactions of a polymer-supported Evans' oxazolidin-2-one

Abstract

A cleavable linker strategy has been used to optimise the enolate alkylation reactions of a recyclable L-tyrosine derived polymer-supported oxazolidin-2-one for the asymmetric synthesis of a series of chiral α-alkyl acids.

Graphical abstract: A cleavable linker strategy for optimising enolate alkylation reactions of a polymer-supported Evans' oxazolidin-2-one

Supplementary files

Article information

Article type
Communication
Submitted
11 Sep 2007
Accepted
13 Nov 2007
First published
29 Nov 2007

Chem. Commun., 2008, 508-510

A cleavable linker strategy for optimising enolate alkylation reactions of a polymer-supported Evans' oxazolidin-2-one

R. Green, A. T. Merritt and S. D. Bull, Chem. Commun., 2008, 508 DOI: 10.1039/B713966G

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