Structural features of the Cu(II) complex with the rat Aβ(1–28) fragment

Elena Gaggelli; Zbigniew Grzonka; Henryk Kozłowski; Caterina Migliorini; Elena Molteni; Daniela Valensin; Gianni Valensin

doi:10.1039/B713453C

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Structural features of the Cu(ii) complex with the rat Aβ(1–28) fragment†

Elena Gaggelli,^a Zbigniew Grzonka,^b Henryk Kozłowski,*^c Caterina Migliorini,^a Elena Molteni,^a Daniela Valensin^a and Gianni Valensin*^a

Author affiliations

* Corresponding authors

^a Department of Chemistry, University of Siena, via Aldo Moro, 53100 Siena, Italy
E-mail: valensin@unisi.it

^b Faculty of Chemistry, University of Gdansk, Gdansk, Poland

^c Faculty of Chemistry, University of Wrocław, F. Joliot-Curie 14, 50-383 Wrocław, Poland
E-mail: henrykoz@wchuwr.chem.uni.wroc.pl

Abstract

The interaction between Cu(II) and the rat amyloid β (1–28) fragment in micellar solutions at pH 7.5 was investigated by CD and NMR spectroscopy; the proton–copper distances were used in restrained molecular dynamics simulations to obtain a structural model of the Cu(II) complex.

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Supplementary files

Peptide synthesis, NMR and CD measurements, molecular dynamics calculations, temperature dependence of R _1p of His-6 and His-14, CD spectra of rAβ in the absence and in the presence of Cu(II), Cu(II)–H distances calculated with different τ _M values PDF (160K)

Article information

DOI: https://doi.org/10.1039/B713453C
Article type: Communication
Submitted: 03 Sep 2007
Accepted: 19 Oct 2007
First published: 29 Oct 2007

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Chem. Commun., 2008, 341-343

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Structural features of the Cu(II) complex with the rat Aβ(1–28) fragment

E. Gaggelli, Z. Grzonka, H. Kozłowski, C. Migliorini, E. Molteni, D. Valensin and G. Valensin, Chem. Commun., 2008, 341 DOI: 10.1039/B713453C

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Chemical Communications

Structural features of the Cu(ii) complex with the rat Aβ(1–28) fragment†

Abstract

Supplementary files

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Structural features of the Cu(II) complex with the rat Aβ(1–28) fragment

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