Issue 2, 2008
From the journal:

Chemical Communications

Synthesis and cytotoxicity of a cobaltcarbonyl–alkyne enkephalin bioconjugate†

Merja A. Neukamm,a   Antonio Pintoa  and  Nils Metzler-Nolte*a  

* Corresponding authors

a Lehrstuhl für Anorganische Chemie I - Bioanorganische Chemie, Fakultät für Chemie und Biochemie, Ruhr-Universität Bochum, Universitätstr. 150, Germany
E-mail: nils.metzler-nolte@rub.de

Abstract

A solid-phase synthesized propargyl derivative of the neuropeptide leucine-enkephalin (Enk) reacts rapidly and quantitatively with Co2(CO)8 to give the Co2(CO)6–alkyne labeled peptide 2, which is the first organometallic peptide bioconjugate to show significant toxicity against two different tumor cell lines.

Graphical abstract: Synthesis and cytotoxicity of a cobaltcarbonyl–alkyne enkephalin bioconjugate

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Article information

DOI
https://doi.org/10.1039/B712886J
Article type
Communication
Submitted
21 Aug 2007
Accepted
25 Sep 2007
First published
22 Oct 2007

Chem. Commun., 2008, 232-234

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Synthesis and cytotoxicity of a cobaltcarbonyl–alkyne enkephalin bioconjugate

M. A. Neukamm, A. Pinto and N. Metzler-Nolte, Chem. Commun., 2008, 232 DOI: 10.1039/B712886J

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